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Tamsulosin hydrochloride 0.4 mg capsule (MediCare, London, UK) each 5 h before the test meal (n = 8, age 21.6 ± 6.3 yr) or for 24 h after the test meal (n = 10, age 22.7 ± 6.1 yr). For the 24-h oral tolerance test after the meal, mice were randomly assigned to receive either the vehicle (no treatment group) or the tamsulosin-treated group (no dose).
Tolerability and Pharmacokinetics
Subjects tolerated the dietary regimen well in that there were no adverse events, and difference was observed between groups for weight, body composition, or food intake over the course of study (Figure 1). This was also the case with administration of each drug, as administered in the mouse diet. Animals tamsulosin-treated group demonstrated a 5.8-fold increase (P < 0.05) in body weight and a 5.3-fold increase (P < 0.05) in the food intake over course of the study compared with animals in What is the generic pill for adderall the vehicle group (Table 2). No significant differences were observed between the administration of tamsulosin and vehicle for any of the parameters analyzed (Figure 1).
Figure 1 View largeDownload slide Mean (±SEM) food and adipose (BMI) weight gain of group I (n = 8), male 6-mo-old C57BL/6J mice in the two test groups following a 12-wk double-blind study in which they received either a vehicle (5% glucose), or tamsulosin (5 mg orally, n = 10) diet. Data are presented as means ± SEM. *, P < 0.05; **, 0.01; ***, P < 0.001; ****, 0.0001.
Table 2 Vehicle group Tamsulosin Tamsulosin/ Male weight* 9.8 ± 0.2 10.5 0.1 10.3 0.1* 9.9 ± 0.2 11.6 0.1 9.3 0.1* Female weight* 5.8 ± 0.0 5.3 0.0* 5.7 5.4 ± 0.0 Body fat percentage* 26.3 ± 0.2 26.6 0.1 25.9 25.6 ± 0.2 26.0 25.7 0.1 Food intake per day* 3050 ± 1030 3200 880 2700 720 safe online pharmacy adderall 3070 ± 620 3000 3200 800 Body composition** Lean tissue* 3.3 (2.7) 3.5 (2.5) 3.2 (2.3) 2.5 2.8 (2.1) 1.2 (1.5) Fat tissue* 29.6 (15.5) 40.0 (13.8) 37.8 (13.3) 44.1 (13.1) 46.6 (16.8) 41.0 (14.4) Lipids** Triglycerides* 8.5 (4.3) 11.0 (4.1)* 10.2 (4.5)* 9.4 (4.4) 10.4 (3.7) (5.2) (4.1) High-density lipoproteins* 1.3 (0.4) 1.6 1.4 (0.5) (0.2) 2.0 (0.6) 1.6 (0.4) Cholesterol 0.7 (0.2) 0.9 0.6 1.0 1.3 (0.3) 1.1 (0.2) Low-density lipoproteins* 1.0 (0.3) 1.4 Generic adderall ir coupon ()